Place lettuce in a mixing bowl. Drizzle with the olive oil, red wine vinegar, and lemon juice. Add the garlic powder, dried oregano, a pinch of salt and pepper, and 1/4 cup Parmesan. Toss to coat, taste, and adjust seasoning if needed. (Careful not to over dress the lettuce—it should be wet, but not soggy.)
Spread marinara sauce in a thin even layer between the tortillas.
Top each with pepperoni (if using), mozzarella, the remaining Parmesan, and a touch of red pepper flakes.
Working in batches, transfer tortilla to an air fryer. Air fryer at 400°F for 4 to 5 minutes until the cheese is melted and browned. Let cool for a few minutes.
Divide the seasoned lettuce between the two cooked cheesy tortillas.